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Open Positions

Please be aware that those listings may be outdated.

Master Project - Cancer Cytogenetics Beacon

This project is based on the premises that:

  • cytogenetic aberration data (e.g. chromosomal translocations) represent an important set of molecular markers, esoecially in hematologic malignancies but also in developmental diseases
  • a large body of such data exists, but is mostly difficult to access and or search, systematically
  • cytogenetic annotations can be converted into modern variant annotation forrmats, such as being developed by the Genomic Knowledge Standards workstream of the Global Alliance for Genomics and Health (GA4GH)
  • an implementation to access genome variant data is the Beacon API
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PhD / Postdoc in Computational Phylogenetics

With the advent of new generation sequencing (NGS) bioinformatic methods must keep pace to provide robust scalable solutions to analyse large sets of molecular sequences. The evolutionary history of molecules is described by a tree structure called phylogeny, which is inferred from genomic sequences. Phylogenies are used for testing biological hypotheses with applications ranging from medicine to ecology. Phylogeny inference usually relies on an inferred alignment of homologous sequences, which – in turn – relies on a guide-tree reflecting their ancestral relationships. The goal is to address this apparent circularity so to improve the reliability of phylogenetic analyses. Ideally alignment and tree should be inferred jointly.

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Master's position in Bioinformatics

The URPP Evolution in Action: From Genomes to Ecosystems is seeking Masters students for projects in bioinformatics. The URPP Evolution in Action involves multiple research groups in biology, and it plays an important integrative role for the diverse biological disciplines at UZH.

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