Nucleosome footprints in the cell-free DNA of cancer patients

Zurich Seminars in Bioinformatics - Zsolt Balázs

  • 12:15 UZH Irchel Y55-l-06/08 and ZOOM Call

Abstract Cell-free DNA (cfDNA) is free floating DNA released from cells into bodily fluids like blood. cfDNA sequencing is being increasingly utilized in cancer diagnosis and monitoring. While many applications focus on detecting cancer-specific mutations, cfDNA can potentially tell us much more about the disease. Nucleosome-protected regions are slow to degrade in the bloodstream, therefore, nucleosome occupancy in the cell of origin can be inferred from cfDNA fragmentation. In this presentation, we are going to present nucleosome footprint analysis, a novel tool in cfDNA fragmentomics and show how it compares to mutation-based approaches when applied to cancer monitoring.

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